The genes located on chromosome 16 (Hillman

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The two major types are called Alpha and Beta
thalassemia, depending on which part of globin chain is made in lower amounts
(Victor et al., 1999). In Alpha Thalassemia, alpha globin chain is formed by
four genes (two from each parent), two on each strand of chromosome 16. The
alpha thalassemia was initiated by 
reduction in the production of alpha globin’s chains due to deletion or
mutation of one or more of the four alpha globin’s genes located on chromosome
16 (Hillman and Ault, 2002). Alpha and Beta. The Beta Thalassemia also known as
Cooley’s Anemia. Beta symptoms were appeared in the first two years of life,
the symptoms include Paleness of the skin, Poor appetite, Irritability. Alpha
Thalassemia also a severe and a very serious disease in which severe Anemia
begins even from birth.

There are more than 200 of alteration within the beta
globin gene endow worldwide to produce beta thalassemia. Unlike the deletion
that compose most of the alpha thalassemia syndromes, beta thalassemia is
inspired by mutation on chromosome 11 that affect all of beta globin
production: transcription, translation, and the reliability of the beta globin
production (Howard et al.,1996)

is hereditarily, meaning that at least one of your parents must be a transporter
of the disease. If one parent has thalassemia minor and other partner also has
thalassemia minor so in that case the child gets thalassemia major. It was
caused by a genetic transmutation or an omission of certain key gene wreckages.

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is a complex group of diseases that are relatively rare in the United States
but common in South and Southeast Asia. Internationally, there are 350,000
births per year with serious hemoglobinopathies (blood disorders).

Quality of life (QOL) is a multidimensional idea
that usually have perspective of positive and negative characteristics of life. The WHO defines quality of life (QOL) as “an individual’s insight of
their situation in life in the framework of the culture and value systems in
which they live and in relation to their goal line, opportunities, morals and apprehensions.
It is a concept that affects person’s physical capability, psychosomatic
well-being, personal beliefs, social relationships and their relationship with
others in their environment.

 Assessing quality of life makes it possible
to measure disease load and can be used to help to regulate risk factors that
may lead to poor quality of life among thalassemia patients.


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