Study time of each blood donation. The

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 Analysis of repeat reactive results for hepatitis B & C screening tests
among voluntary non-remunerated blood donors at National Blood Centre from
January 2017 to June 2018



and Justification

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Transfusion Transmissible infections are an important limiting factor in transfusion services1,2. It is the responsibility of blood transfusion services to provide a safe and sufficient supply of blood and blood products to all patients who require a transfusion. More viruses such as HIV, Hepatitis B, Hepatitis C, CMV, EBV, WNV have a significant effect on blood transfusion services in the world. In Sri Lanka, hundred percentage of the donated blood received from voluntary nonremunerated donors. Before the blood donation, each blood donor will counsel and examine by a medical officer and pre-check will be done by PHI. All donated blood samples will screen for HIV, hepatitis B and hepatitis C, syphilis and malaria. Our national blood center has a strict quality control system which works in association with international laboratories to confirm high standards. Sri Lankan blood donors have lower Transfusion-transmissible infection rates when compare with other countries in the region. Hepatitis B virus (HBV) remains a major risk of transfusion-transmitted infections as a result of the pre-seroconversion period (WP), infection with immunovariant viruses and occult transmission of HBV infection (OBI). Reduction of outstanding risk on HBV depends on the development of more sensitive HBV surface antigen (HBsAg) tests, and HBV nucleic acid tests (NAT). Despite important improvements in blood donation screening, hepatitis B virus infection (HBV) remains a major risk for transfusion-mediated viral infection. The remaining risk of transfusion-transmitted infection is the highest for HBV compared to hepatitis C or HIV, mainly because HBV screening is based solely on hepatitis B surface antigen. The detection of HBs antigen in the serum or plasma indicates an infection caused by the hepatitis B virus. It is the first marker that appears and can be observed two or weeks before the clinical and biological symptoms of the disease. The presence period can be very short or very long. HBs antigen that persists for more than 6 months in the serum indicates chronic hepatitis. Because of the existence of the numerous asymptomatic chronic carriers, hepatitis B represents a major risk of transfusion and the prevention of transmission is based on the detection of the HBs antigen at the time of each blood donation. The Monolisa HBs Ag ULTRA assay is a qualitative one-step “sandwich” enzyme immunoassay for the detection of hepatitis B virus surface antigen (HBs Ag) in human serum or plasma. This test is intended for the diagnostic use and detection of blood donations in MRI and NBTS


hepatitis C virus (HCV) is an enveloped RNA virus that belongs to the family of
flavivirids, of which six major genotypes were identified. HCV is recognized as
the main cause of non-A and non-B viral hepatitis. HCV infection is
characterized by an acute and chronic condition that can lead to cirrhosis and
hepatocellular carcinoma.

evidence of HCV infection can be obtained through blood tests to detect HCV
antigens and / or antibodies and / or RNA. Compared to a test for anti-HCV
antibodies alone, the use of a combined screening test for both anti-HCV
antibodies and for HCV capsid antigen can reduce the serological window period
and improve the detection of the infection.

 Monolisa HCV Ag-Ab ULTRA  is a qualitative enzyme immunoassay for the detection of infection by the hepatitis C virus (HCV) based on the detection of anti-HCV antibodies and capsid antigen in human serum or plasma. This hepatitis C screening test is used by both MRI and NBTS 





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