Parkinson’s consequence of death of cells in
disease is a neurodegenerative disorder, leading to progressive degeneration of
motor functions of the patients due to death of dopamine-producing brain cells.
In early stages of the disease, the most commonly visible symptoms are rigidity,
shaking, slowness of movement, and difficulty with walking. Thinking problems
and behavioral changes can also be noticed. Dementia is common among the
patients in advanced stages of the disease. Anxiety and depression are also some
common traits observed in more than one third of people with PD. More symptoms
include emotional, sensory and sleep problems. The main motor symptoms are
collectively called “parkinsonism”, or a “parkinsonian
syndrome”. Patients’ voice tends to stutter and progressively becomes
affected as the disease becomes more severe.
The motor symptoms of the disease are a consequence of death of cells in substantia
nigra, a region present in the midbrain. Due to this, there arises the shortage of
dopamine in these areas. Although the cause for this cell death cannot be
properly understood, it involves the build-up of proteins into Lewy bodies in
There is no cure for this disease, however treatment is directed towards
improving symptoms. Treatment usually starts with the antiparkinson medication
levodopa (L-DOPA). As the disease advances and neurons continue to be lost, the
medications lose their effectiveness. Moreover, they tend to produce a
complication caused by involuntary twitching movements. However, some forms of
rehabilitation and diet plans have been noticed to improve the symptoms. Placing
microelectrodes through surgery for deep brain stimulation is now used to lessen
the symptoms complying with motor abilities in cases where drugs prove to be
The organisation of our paper is as follows: First, we explain the objective of
our research followed by discussing the related previous works in this field.
Then, we describe our proposed methodology and the experimentation work.
Finally, we conclude with accuracy and data analysis results and future scope
of our research which could further better the output.