Nanotechnological the next generation in the fight against

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applications in medicine have yielded a completely new field of technology that
is set to bring momentous advances in the fight against a range of diseases1.
Nanoscale particles have emerged as novel microbial agents owing to the high
surface area to volume ratio, which is coming up as the current interest in the
researchers due to the growing microbial resistances against metal ions,
antibiotics and the development of resistant strains 2 . Many nanoparticles
have antimicrobial efficiency and used to control drug-resistant microbial
populations.3 Different inorganic metal oxide nanoparticles such as, ZnO,
MgO, TiO2 and SiO2 exhibit considerable antimicrobial
activities and used in therapeutics, diagnostics, and nanomedicine-based
antimicrobial agents.4,5 Inorganic nanoparticles show greater effectively on
resistant strains of microbial pathogens, less toxicity, heat resistance and
provide mineral elements essential to human cells 6. Among these metal oxides
nanomaterials, ZnO is of special attention, due to its established use in
healthcare products, UV blocking capability, biocompatibility and modest cost
7. Microbial contamination is a serious issue in healthcare and food industry
so that the development of antimicrobial agents and surface coatings has been
attracting increasing attention in recent years 8.Zinc oxide nanoparticles
are known to be one of the multifunctional inorganic nanoparticles with
effective antibacterial activity. Antibacterial and antifungal activities of
zinc oxide nanoparticles are observed even at very lower concentrations and
also the antifungal activity does not influence soil fertility compared to the
conventional antifungal agents9.Many researchers reported the properties of
ZnO can be tuned by doping with various metal ions 10,11. The transition
metals (Ni, Co, Al, Cu, Ag) doped ZnO display best properties, as transition
metal elements have close ionic radius parameter to that of Zn2+,
which means that these elements can easily penetrate into ZnO crystal lattice
or substitute Zn2+ position in crystal 12. Doped transition metals
in zinc oxide optimize the electronic, magnetic, optical, and electrical
characterization that are useful for different practical applications
12.Doped ZnO shows a maximum effect against pathogenic organisms as compared
to ZnO, thereby using nanoparticles as an antimicrobial agent and was one of
the most useful techniques to control pharmacy chemical waste and cost
effect13. Ni is an important dopant in these magnetic materials. Furthermore,
Ni+2 (0.69 A ° ) has the same valence as Zn+2 and its
radius is close to that of Zn+2 (0.74 A ° ), so it is possible for
Ni+2 to replace Zn+2 in ZnO lattice. Some researchers
reported that the luminescence properties of zinc oxide were changed after
doping of Ni 14.

aim of the present work was to synthesize and 
structural characterize of  zinc
oxide nanoparticles doped with cobalt and nickal  by a chemical co-precipitin method. It s also
would become the next generation in the fight against microbial infections

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